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乳液冷冻干燥法制备壳聚糖/聚乳酸复合材料

黄天辉 郭晓霖

黄天辉, 郭晓霖. 乳液冷冻干燥法制备壳聚糖/聚乳酸复合材料[J]. 北京航空航天大学学报, 2017, 43(1): 1-6. doi: 10.13700/j.bh.1001-5965.2016.0051
引用本文: 黄天辉, 郭晓霖. 乳液冷冻干燥法制备壳聚糖/聚乳酸复合材料[J]. 北京航空航天大学学报, 2017, 43(1): 1-6. doi: 10.13700/j.bh.1001-5965.2016.0051
HUANG Tianhui, GUO Xiaolin. Chitosan/polylactic acid composites prepared by emulsion freeze-drying technique[J]. Journal of Beijing University of Aeronautics and Astronautics, 2017, 43(1): 1-6. doi: 10.13700/j.bh.1001-5965.2016.0051(in Chinese)
Citation: HUANG Tianhui, GUO Xiaolin. Chitosan/polylactic acid composites prepared by emulsion freeze-drying technique[J]. Journal of Beijing University of Aeronautics and Astronautics, 2017, 43(1): 1-6. doi: 10.13700/j.bh.1001-5965.2016.0051(in Chinese)

乳液冷冻干燥法制备壳聚糖/聚乳酸复合材料

doi: 10.13700/j.bh.1001-5965.2016.0051
基金项目: 

国家科技支撑计划 2012BAI18B01

详细信息
    通讯作者:

    黄天辉,男,博士,副教授。主要研究方向:新材料。E-mail:18677191775@163.com.

  • 中图分类号: R318.08;TB332

Chitosan/polylactic acid composites prepared by emulsion freeze-drying technique

Funds: 

National Science & Technology Pillar Program of China 2012BAI18B01

More Information
  • 摘要:

    亲水性细胞外基质聚糖和疏水性脂肪族聚酯材料之间的复合是生物材料研究面临的巨大挑战。本研究以亲水性壳聚糖(CS)的醋酸溶液为水相,疏水性聚乳酸(PLA)的CHCl3溶液为油相,Tween80为表面活性剂,采用乳液冷冻干燥法制备了CS/PLA复合材料。FTIR分析发现,复合材料中CS和PLA组分间存在强烈的氢键相互作用。SEM观察表明,控制PLA的体积分数不高于50%,则复合材料的孔隙结构相互贯通,CS和PLA分布均匀。CS/PLA复合材料的孔隙率介于85%~90%,并且随PLA用量的增加,孔隙率略有下降。当PLA用量体积分数由25%增加到75%时,复合材料的力学性能介于CS和PLA的力学性能之间,其压缩强度由0.20 MPa增加到0.33 MPa,压缩模量由2.84 MPa增加到4.83 MPa。这种CS/PLA两亲复合体系为新型生物材料的设计和构建提供了新方法。

     

  • 图 1  CS、PLA以及CS/PLA复合材料的FTIR谱图

    Figure 1.  FTIR spectra of CS,PLA and CS/PLA composites

    图 2  CS、 PLA以及CS/PLA复合材料的SEM照片

    Figure 2.  SEM photographs of CS,PLA andCS/PLA composites

    图 3  CS/PLA复合材料的孔径分布

    Figure 3.  Pore size distribution of CS/PLA composites

    图 4  CS、 PLA以及CS/PLA复合材料的压缩强度和压缩模量

    Figure 4.  Compressive strength and compressive modulus ofCS,PLA and CS/PLA composites

    表  1  CS、PLA以及CS/PLA复合材料的孔隙率

    Table  1.   Porosity of CS,PLA and CS/PLAcomposites

    样品 孔隙率/%
    CS 96.8±0.8
    CS/PLA-1 89.8±1.8
    CS/PLA-2 88.5±2.1
    CS/PLA-3 87.1±1.5
    PLA 83.1±1.2
    下载: 导出CSV
  • [1] PLACE E S,EVANS N D,STEVENS M M.Complexity in biomaterials for tissue engineering[J].Nature Materials,2009,8:457-470. doi: 10.1038/nmat2441
    [2] WILLIAMS D F.On the nature of biomaterials[J].Biomaterials,2009,30:5897-5909. doi: 10.1016/j.biomaterials.2009.07.027
    [3] HUEBSCH N,MOONEY D J.Inspiration and application in the evolution of biomaterials[J].Nature,2009,462(7272):426-432. doi: 10.1038/nature08601
    [4] MUNCH E,LAUNEY M E,ALSEM D H,et al.Tough,bio-inspired hybrid materials[J].Science,2008,322(5907):1516-1520. doi: 10.1126/science.1164865
    [5] NIU X F,LUO Y F,LI Y G,et al.Design of bioinspired polymeric materials based on poly(D,L-lactic acid) modifications towards improving its cytocompatibility[J].Journal of Biomedical Materials Research Part A,2008,84A(4):908-916. doi: 10.1002/(ISSN)1552-4965
    [6] BODDOHI S,KIPPER M J.Engineering nanoassemblies of polysaccharides[J].Advanced Materials,2010,22(28):2998-3016. doi: 10.1002/adma.v22:28
    [7] GUPTA B,REVAGADE N,HILBORN J.Poly(lactic acid) fiber:An overview[J].Progress in Polymer Science,2007,32(4):455-482. doi: 10.1016/j.progpolymsci.2007.01.005
    [8] BHATTARAI N,LI Z S,GUNN J,et al.Natural-synthetic polyblend nanofibers for biomedical applications[J].Advanced Materials,2009,21(27):2792-2797. doi: 10.1002/adma.200802513
    [9] AMIDI M,HENNINK W E.Chitosan-based formulations of drugs,imaging agents and biotherapeutics preface[J].Advanced Drug Delivery Reviews,2010,62(1):1-118. doi: 10.1016/j.addr.2009.12.006
    [10] STUART M A C,HUCK W T S,GENZER J,et al.Emerging applications of stimuli-responsive polymer materials[J].Nature Materials,2010,9(2):101-113. doi: 10.1038/nmat2614
    [11] NIU X F,FENG Q L,WANG M B,et al.In vitro degradation and release behavior of porous poly(lactic acid) scaffolds containing chitosan microspheres as a carrier for BMP-2-derived synthetic peptide[J]. Polymer Degradation and Stability,2009,94(2):176-182. doi: 10.1016/j.polymdegradstab.2008.11.008
    [12] NIU X F,FENG Q L,WANG M B,et al.Preparation and characterization of chitosan microspheres for controlled release of synthetic oligopeptide derived from BMP-2[J].Journal of Microencapsulation,2009,26(4):297-305. doi: 10.1080/02652040802319742
    [13] 牛旭锋,冯庆玲,王明波,等.微囊化壳聚糖/纳米羟基磷灰石/胶原/聚乳酸复合材料[J].复合材料学报,2009,26(2):143-148. http://www.cnki.com.cn/Article/CJFDTOTAL-FUHE200902027.htm

    NIU X F,FENG Q L,WANG M B,et al.Chitosan microspheres/nano-hydroxyapatite/collagen/polylactide composite[J].Acta Materiae Compositae Sinica,2009,26(2):143-148(in Chinese). http://www.cnki.com.cn/Article/CJFDTOTAL-FUHE200902027.htm
    [14] WAN Y,FANG Y,WU H,et al.Porous polylactide/chitosan scaffolds for tissue engineering[J].Journal of Biomedical Materials Research Part A,2007,80A(4):776-789. doi: 10.1002/(ISSN)1552-4965
    [15] RASAL R M,JANORKAR A V,HIRT D E.Poly(lactic acid) modifications[J].Progress in Polymer Science,2010,35(3):338-356. doi: 10.1016/j.progpolymsci.2009.12.003
    [16] DING Z,CHEN J N,GAO S Y,et al.Immobilization of chitosan onto poly-L-lactic acid film surface by plasma graft polymerization to control the morphology of fibroblast and liver cells[J].Biomaterials,2004,25(6):1059-1067. doi: 10.1016/S0142-9612(03)00615-X
    [17] LIM S M,SONG D K,OH S H,et al.In vitro and in vivo degradation behavior of acetylated chitosan porous beads[J].Journal of Biomaterials Science-Polymer Edition,2008,19(4):453-466. doi: 10.1163/156856208783719482
    [18] WAN Y,WU H,YU A X,et al.Biodegradable polylactide/chitosan blend membranes[J].Biomacromolecules,2006,7(4):1362-1372. doi: 10.1021/bm0600825
    [19] NIU X F,FENG Q L,WANG M B,et al.Porous nano-HA/collagen/PLLA scaffold containing chitosan microspheres for controlled delivery of synthetic peptide derived from BMP-2[J].Journal of Controlled Release,2009,134(2):111-117. doi: 10.1016/j.jconrel.2008.11.020
    [20] HONG Z,REIS R L,MANO J F.Preparation and in vitro characterization of scaffolds of poly(L-lactic acid) containing bioactive glass ceramic nanoparticles[J].Acta Biomaterialia,2008,4(5):1297-1306. doi: 10.1016/j.actbio.2008.03.007
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出版历程
  • 收稿日期:  2016-01-15
  • 录用日期:  2016-04-15
  • 网络出版日期:  2017-01-20

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