It was validated that Fluent can be used in numerical simulation on lateral jet interaction by comparing with the experimental results. Using Fluent, the lateral jet characteristics at different jet pressures and different angles of attack in supersonic flows is numerically investigated. The results indicate that in supersonic flows, with increasing of jet pressures, the high pressure region before lateral jet enlarged, and the wraparound effect strengthened. In the cases of angles of attack, comparing to windward side jet, the high pressure region before the leeward side jet enlarged, the jet wraparound effect in the region of leeward side moved forward, and the control of leeward side jet was more effective. The affected regions of wraparound effect is confined in regions from 0° to 90° on missile surface.