Abstract: As self-management cluster with professional characteristics in the field of science and technology, the science and technology cluster has not only a special meaning for any individual subject in this field, but also for the whole development and even the national strategy of "Rejuvenating the Country through Science and Technology". To carry out the reform of scientific and technological cluster, we must first understand its history and uniqueness. As a special creation of the Communist Party of China to govern the society, the science and technology cluster is a political and social organization system with a characteristics of dynamic "core-periphery" gradually formed in the process of revolution and construction, relying on its own network in dealing with the complex social system and integrating various political powers. The cluster plays an important role in respective areas in social guide, organization, and management. In order to carry out the reform of scientific and technological cluster organizations, it is necessary to stand in the new era and put forward new requirements for its nature and functions. Therefore, the further reform and development of the science and technology cluster needs to clarify three logics, namely Chinese logic, times logic and theory logic. In general, the scientific and technological cluster should pay attention to the dual nature of its political and social organizations in the reform. Accordingly coupling paths should be taken in the reform of the double main body structure, promoting political attribute, emphasizing the social organization attributes, and strengthening full self-independence and the establishment of a set of governance structure system with the function of self-organization and self-management. All these should be conducted within the laws, party rules and self-reliance regulations to complete the reform.