Abstract: Based on the data of 77 cities in China from 2004 to 2012, the STIRPAT model combined with linear mixed model is constructed to study the influencing factors of urban industrial pollution in eastern, central and western regions of China. The results show that, as a whole, with the expansion of population size, urbanization process and the industrialization process, industrial pollution will be significantly increasing. Improvements in the energy consumption structure will help reducing industrial pollution. At the same time, there is a "U" shape Kuznets curve of industrial pollution in China's urbans. With GDP per capita growing, industrial pollution firstly decreases and then increases. The impact of population size on industrial pollution varies with regions. This influence in the western region is greater than that in the eastern and central regions. Policy implications for controlling industrial pollution in Chinese cities will be provided.