Abstract: Between change and invariance, invariance is the insistence on direction, and change is a response to innovation. In the new era, ideological and political theory course is the main front and channel for university students to carry out Marx theory education. Therefore, when it comes to the fundamental aspects of the ideological and political theory course, it is necessary to keep invariance. At the same time, in the face of changes in various aspects, the ideological and political theory course in universities should be ahead of the time to recognize changes, actively respond to changes, and actively seek changes, so as to promote the "living" of the ideological and political theory course in universities. In short, we should not only enhance the ideological aspects and theoretical, but also the affinity and pertinence of the ideological and political theory courses in universities in the process of "change" and "invariance"