Abstract: COVID-19 epidemic prevention and control provides a series of vivid teaching materials for the teaching of the course of Introduction to Mao Zedong Thought and the theoretical system of socialism with Chinese characteristics (hereinafter referred to as the course of Introduction). However, due to the large number and wide range of involved points, the integration of "epidemic prevention and control" into the teaching is faced with practical challenges. Therefore, teachers not only need to closely combine the teaching key points, difficulties and students' concerns of the course to carry out the overall planning and system integration of the teaching content, but also need to guide students to enter the deep learning by restoring the complex situation, encouraging students to read deeply and focus on discussion and other teaching methods optimization.