Abstract: As an important part of the university's modern governance system and governance capacity, governance of science and technology is the epitome of high-quality and connotative development ability of higher education in the field of technological innovation and governance. Governance of science and technology in the modern era is the fundamental requirement of the new era and new mission for universities to support the national strategy and promote the country's development by innovation. This goverance includes not only the system and mechanism, policies and regulations, support and guarantee system, which are closely linked and coordinated to promote the development of science and technology in universities, but also the comprehensive management ability to enhance the strength and level of scientific and technological innovation by using modern management methods. Under the background of the new era, the framework of university's modern governance of science and technology in modern era can be summed up as the internal logic of "two dimensions, three levels, four modernizations, five fusions and six cores". To promote the efficiency of modern governance of science and technology in universities during the 14th five-year plan period, we should consummate the top-layer design of the science and technology governance system, create an open and inclusive environment for independent innovation, strengthen the effect diffusion of university science and technology governance system and mode, enhance the traction advantage of science and technology independent innovation, promote the coupling of internal and external science and technology governance network mechanism, build a collaborative governance community of scientific and technological innovation, explore and establish university science and technology governance strategic alliance, and finally build a multi-level and multi-span collaborative governance network.