Abstract: Biomedical engineering includes many research directions, and many related courses are not yet mature, which restricts to a certain extent the cultivation of first-class medical-engineering talents in China. The present paper introduces the exploration and practice of the course team in the construction of medical-engineering courses in the past years from three aspects: training of medical-engineering thinking mode, referring to and remodeling of foreign high quality courses, and ideological and political education in the courses. Specifically, centered on clinical problems, the research-based teaching is conducted, and students are instructed to actively analyze and solve clinical problems from an engineering perspective, so as to cultivate students' medical-engineering thinking mode. Foreign high-quality courses are absorbed and reconstructed according to "Golden Course" standards and the current status of the medical industry in China. The Chinese elements in the curriculum are excavated. Based on "Healthy China" and other major national strategies of biosafety, the ideological and political education is carried out naturally in the course.