Abstract: In the era of new technological revolution, science and engineering universities are committed to cultivating compound innovative scientific and technological talents with solid professional foundation, extensive knowledge, and good qualities. Liberal arts general education aims to internalize the humanistic spirits in the era of globalization.Liberal arts general education courses for science and engineering students need the integration of explicit teaching curriculum design and implicit teaching interaction to effectively realize the internalization of humanistic spirits. The course of Intercultural Communication adopts the culturally responsive teaching model, integrating explicit and implicit teaching into a multicultural teaching scene. In the teaching process, students are led to comprehend the local culture and reflect on "stereotypes" of other cultures, so as to expand global perspectives and undertake international responsibilities. Students are encouraged to broaden the breadth of life with the experience of teachers. Through the teaching practice, it is found that high-quality liberal arts general education courses can have a non-negligible value for science and engineering students to develop humanistic spirits, inspire ideas and beliefs, enhance sense of social responsibility, and improve interpersonal relationships.