Abstract: The obstacles to legal cooperation in civil aviation among Guangdong, Hong Kong and Macao are mainly due to differences and legal conflicts in legislation and industry supervision. Given the highly international nature of civil aviation, we can eliminate the gap between jurisdictions and legal systems by investigating the existing model samples of interregional legal cooperation and drawing on the commonality of legal culture and the consensus on aviation safety in the three regions. The institutional differences, under the framework of “one country, two systems and three jurisdictions” in the Greater Bay Area, can be transformed into developmental advantages to establish the foundation for legal cooperation in civil aviation. This paper suggests pathways for promoting such cooperation among Guangdong, Hong Kong and Macao through building a diversified legislative model of legal cooperation in civil aviation, a regional coordination mechanism, and a legal consortium of civil aviation in the Greater Bay Area.