Abstract: The rationality of comparing corruption to disease stems from the similarities between the two in their emergent features and ideas for the counter measures. And it's obvious that corruption demonstrates infectious characteristics and unique infectious mechanism from the perspective of disease. Thus, it is reasonable to make comparisons between corruption and infectious disease, and between anti-corruption and prevention and control of Covid-19 pandemic respectively. No matter where the Covid-19 occurs China has always been able to curb its spread. The two key factors for China's success are its rapid response and determination. In comparison with China's previous anti-corruption work, it's found that it is difficult to take rapid and determined actions and the two underlying reasons behind the di-fficulty are the timing and the institutional factors. Therefore, it is imperative to make determination to implement a new strategy to combat corruption, and proceed to deepen the reform of discipline inspection and supervision system.