Abstract: As corruption offenders tend to become younger, college students'perception of incorruptibility has attracted wide attention from academia and society. Anti-corruption news is an important source of information for college students to form their perception of incorruptibility and new media has become the primary channel for college students to have access to anti-corruption news. From the perspective of media dissemination of anti-corruption news, this paper discusses the influence mechanism of college students' perception of incorruptibility. The results show that the agenda setting of anti-corruption news, such as subject content, emotion expression, value standpoint and evaluation orientation, has a dual impact on college students' perception of incorruptibility, which is a comprehensive representation of the mechanisms of information cognition, emotion identification, value consensus and behavior practice in the process of media dissemimination of anti-corruption news.To improve college students' perception of incorruptibility and cultivate a group of incorruptible college students with knowledge and action in the new era, it is necessary to take the optimization of the agenda setting of anti-corruption news as the starting point, improve the presentation of news content to enhance college students' cognitive ability of incorruptibility, and adopt positive emotion expressions in the news to cultivate their emotional resonance of incorruptibility. In addition, it is also essential to spread mainstream value concepts to strengthen their will identity of incorruptibility, and createa clean field of public opinion to encourage them to practice incorruptible behavior.