Abstract: The new liberal arts initiative is an inevitable choice for the innovation and development of higher education of liberal arts in the new era in China. From the perspective of the construction of new liberal arts, the construction of public administration discipline and the cultivation of high-quality talents are faced with many opportunities, problems, and challenges, including the opportunities brought by the highly integrated development of the new sci-tech revolution and public administration, the new problems caused by this great consistency of the new point in history with the new mission of public governance, and the new challenges to public administration posed by the situation and dilemma of globalization. Taking Beihang University as an example, this paper discusses the ideas and development goals of the construction of public administration discipline in universities of science and engineering, that is, "intersection between different disciplines and cultivating innovation", as well as the general idea, development path and measures for the cultivation of talents in public administration under the background of new liberal arts. It is proposed that faced with the trend of overall innovation in the construction of new liberal arts in the new era, the construction of public administration discipline in China should be oriented to meet the great needs of the country, adhere to the principles of combining particularity with universality, public value with public practice, and integrate multiple disciplines and new sci-tech methods into discipline construction and the cultivation of high-quality talents. In addition, it is necessary to change from the mode of "extensive development" to the mode of "intensive development" which emphasizes structural optimization, quality improvement, distinctive features, technology empowerment, and strength enhancement.