Abstract: This paper aims to discuss the influence and mechanism of digital infrastructure construction on the high-quality development of low-altitude economy in China. By constructing a theoretical framework and empirical model, and using panel data from 30 provinces in China from 2012 to 2022 for analysis, it is found that the construction of digital infrastructure has significantly promoted the high-quality development of the low-altitude economy. The study further discovers the mediating effects of talent agglomeration, entrepreneurial activity, and inclusive digital finance. In addition, the study finds that entrepreneurial activity and the level of industrial advancement have threshold effects, and there are heterogeneous effects of inter-regional general budget expenditures and urban-rural income disparities on the regression results. Based on the regression analysis results, the following policy recommendations are proposed: Strengthen the construction of digital infrastructure, especially in the central and western regions; Optimize talent training and introduction policies to promote talent agglomeration; Stimulate entrepreneurial vitality, reduce entrepreneurial costs, and promote the development of new business models; Develop inclusive digital finance.