Abstract: APEC Science and Technology Innovation (STI) cooperation is of great significance to the sustainable and balanced development of economy society in APEC area. Based on the "Advocacy Coalition Framework", this paper maintains that APEC members constitute three kinds of advocacy coalitions with different belief systems, and the coalition conflicts result in tardy progress in APEC STI cooperation. Policy learning is an important way to solve coalition conflicts. Analysis in three aspects of conflict degree, problem analyzability and professional forum shows that the possibility of coalition policy learning in APEC STI cooperation is insufficient. Suggestions including clear policy belief, increasing analyzability, and enhancing communication are proposed to promote coalition policy learning, so as to improve the result of APEC STI cooperation.