Abstract: As a public health crisis that ravages the world, the corona virus disease 2019 (COVID-19) has received global attention. The Central Committee of the Communist Party of China puts the safety of the people's lives first, organizes all parties to carry out joint prevention and control, and conducts coordinated governance with international organizations and countries with overseas virus spread. All-round joint defense and joint control demonstrates the advantages of the linkage mechanism under the unitary state system—"centralized all efforts for significant projects". The practise proves that, on the basis of multi-agent collaboration among central regions, local regions and departments, etc., multi-factor collaboration is also needed from the aspects of human resource transfer and allocation, information resource interconnection and sharing, material resource financing and deployment, and technological resource innovation and exchange. Meanwhile, it is necessary to improve the coordination mechanism of organization, mobilization, decision-making, command and execution to fight against the epidemic more efficiently and accurately in collaboration.