Abstract: Grassroots units are the foundation for the safety and stability work in colleges and universities, and the index system is a guide for the scientific and standardized safety construction of grassroots units. Based on the analytic hierarchy process, the paper determines the weights of the indexes at the criterion level and the index level by following the steps of establishing a hierarchical structure model of the index system, scoring by experts, constructing a judgment matrix, and making hierarchical single arrangement and hierarchical total arrangement, and proposes an operable method for refining and quantifying indexes at the final level, thus constructing an index system for the safety construction for grassroots units in colleges and universities. The index system has achieved good results in the practice of safety construction in the secondary departments in many colleges and universities in Beijing.