Abstract: Ideological and political education is the "first class" and main battlefield of the "four comprehensive" strategic layout at universities. As the main channel of college students' ideological and political education, ideological and political course should be given full play. The paper discusses how to actively promote "four comprehensive" strategic layout of "into teaching materials, into classrooms, into minds of college students", which is an important task to strengthen the construction of ideology at universities. In implementing "four comprehensive" strategic layout, the ideological and political course should be problem-oriented, showing students the spiritual essence of "four comprehensive" strategic layout, helping the students establish a correct world outlook, outlook on life and value.