Abstract: A novel predictive guidance was presented for the reentry vehicles based on the fuzzy logic system, according to the requirement of real-time capability. The relation of reentry vehicles- altitude, range and flight path angle was analysed firstly. The system of fuzzy logic was designed with altitude and deviation on target as system inputs and the angular rate of flight path angle as system output. The system took advantage of the experts- experiences to construct the fuzzy rules. Then a novel predictive guidance method was devised following the fuzzy logic which was used for guidance command generation. The method avoids massive iteration computation of general predictive guidance when calculating the angular rate of flight path angle revision command and decreases calculating time of predictive guidance to a satisfactory level effectively. The simulation results indicate the strong anti-interference capacity, high guidance precision and great practical value in engineering of this new predictive guidance method.