Abstract: To solve the problem of continuum-based structural topology optimization under large deformation loading, the hybrid cellular automata (HCA) paradigm for multi-domain topology optimization technique was proposed, a relative density-based material parameterization was developed to model both elastic and plastic material behavior. The state of each cellular automata (CA) was defined by the density and strain energy density, and the uniform strain energy distribution of each design domain was realized by modification the relative density in accordance with CA local control rules. The multi-domain optimization HCA algorithm and convergence strategies were also discussed, these strategies include the simultaneous design of multiple, coupled components and converged individually. An example of bumper structure was presented to demonstrate the results of the multi-domain HCA algorithm, the bumper generated by the HCA algorithm for reduce the peak of reaction force 54% at a suitable sacrifice of stiffness.