Improving the specific stiffness of moving structure is important for the improvement of the machining accuracy and dynamic performance of high speed machine tools. Based on structural bionic theory, through study on the contribution of biologic skeleton to organism stiffness and the concept that biologic skeleton shows the best load path of organism, the column-s inner structure was redesigned as skeleton to improve the specific stiffness. The static, modal, and transient analyses of original column and bionic column were carried out, and the results are satisfying. The FEA results show that through structural bionic design the column-s mass was decreased, the specific stiffness structural efficiency and the natural frequency were improved, the transient displacement was decreased, and the stability of bionic column was better than that of original column. Through structural bionic design the static and dynamic character of column was ameliorated.