Abstract: The whole process of missile overall project design is described by an example of air-to-air missile design, and the flow-chart is showed for demonstrating the procedure clearly. The method for the project evaluation and the way to confirm the weights used in the project evaluation are introduced. Through the human-computer interaction, the missile overall project design will be completed on the computer better than the traditional design method. The results of air-to-air missile design show that the method is effective. Then some problems to which should be paid attention are pinpointed.