Abstract: The error caused by the calculating time delay of predictive guidance was analyzed for the mixed guidance based on the reference-trajectory guidance and predictive guidance for reentry vehicles. The method of error compensation was put forward. By utilizing the optimization theory, performance index function was designed and a new predictive guidance method was proposed. The reference-trajectory guidance was combined with predictive guidance which was applied in some characteristic position in the reentry process. A mixed guidance method based on the optimization for the reentry vehicles was proposed, which decreased calculating time of predictive guidance to a satisfactory level and reduced deviation and disturbance further. The simulation results indicate the strong antiinterference capacity, high guidance precision and great practical value in engineering of this method.