Abstract: Based on approximate models and genetic arithmetic, a scheme for the plane with multi-flaps was proposed to implement the multidisciplinary design optimization (MDO) of full-envelope flight control law and control effectors- geometry & their placement. The robust gain-schedule control method was applied to develop the full-envelope flight control system with the form of moment control in this scheme, and design of experiment (DOE) method as well as radial basis function nerve-network (RBF NN) response surface method was used to obtain approximate models for aerodynamics discipline and control discipline. Then the optimized design parameters were achieved with the genetic arithmetic based on approximate models, and the optimized flight control low & control effectors were finally obtained. On the computer the scheme was validated for a tailless plane with multi-flaps. The simulation result shows the feasibility of the scheme.