Abstract: Performace of compact peripheral component interconnect (CompactPCI )bus and other industrial buses were compared and analyzed, some key technolgies in research and implementation of multiplex telemetry signal simulate source based on CompactPCI bus were introduced, the software interface of simulate source were also described. The general testing environment of the satellite test control system, which based on CompactPCI bus, need generate a large amount of simulation signals from sensors as the source of remote sensing. So it is difficult to achieve 128 ways DA output on single 6U CompactPCI board, if still using traditional sampling circuit and the DA integrated mode. Based on the 8-channel 10bits serial bus controlled DA chip AD5318 produced by analog devices company, it realizes the direct communication between CompactPCI interface chip through simple interface circuits, greatly reducing the amounts of devices on the board and finishing 128-routed output. At the same time, this design also implements a 16 bits AD cored high accuracy feedback loop on the board, dynamically monitoring and regulating each output channel, guaranteeing the DA precision and validating the performance of telemetering collection system.