Preparation of in Vivo Degradable Material Used in Bone Fixation
-
摘要: 为制备强度和韧性都适中且可体内降解的骨固定材料,首先借助聚D,L丙交酯与聚己内酯的扩链反应获得一系列扩链反应聚合物;然后通过测定聚合物拉伸强度和降解性能随扩链剂和扩链反应条件的变化规律,来选择扩链剂和制定最佳制备工艺.利用按上述方法选定的扩链剂和制备工艺,最终制备出了拉伸强度为24.47MPa,延伸率为1091%,降解时间为6个月,且对人体无害的骨固定材料.Abstract: To develop a kind of material with moderale strength and flexibility for bone fixation. First a series of product polymeric on chain reaction was obtained between poly D,L lactide and poly several lactore. Then to detect change regulation which tensile strength and degrading properties of product polymeric following extending chain agent and extending chain reaction condition, extending chain agent was selected and the best technology was formulated. With the above method, the polymeric of bone fixation was made, which is harmless to human body.The tensile strength of this product polymeric is 24.47 MPa, and its breaking elengation ratio is 1091%, to degrade it need six months.
-
Key words:
- chain extendors /
- degradation /
- polycaprolactone /
- poly D,L lactide
-
[1] 李孝红,袁朋龙,能成东.聚乳酸及其共聚物的合成和在生物医学上的应用[J].高分子通报,1999,(3):24~28 Li Xiaohong,Yuan Penglong,Neng Chengdong. Compound of poly lactide with its polymen and apply in biomedical[J]. Polymer Bulletin, 1999,(3):24~28(in Chinese) [2] Bostman O M, Absorbable implant for the fixation of fracture. J Bone Joint Surg,1991,(73):148~150 [3] Matsusue Y, Hanafusa S, Yamamuro T, et al. Tissue reaction of bioabsorbable ultro high strengh poly(L-lactide) rod[J]. Clin Orthop,1995,(317):246~248 [4] Ajioka M, Enomoto K, Suzuki K. et al. Poly with improved heat stability and high molecularweight[J].Bull Chem Soc Jpn,1995,(68):21~25 [5] Bergsmo J E, Rozema F R, Bos R M, et al. Forgein body reactions to restorable poly lactide bone plate and screws used for the fixation of unstable zygomatic fractures[J]. J Oral Maxillofac Surg,1993,(51):66~69 [6] 张贞浴,刘艳红,于 佳,等.聚丙交酯的合成及降解速率的研究[J].黑龙江大学自然科学学报,1998,15(2):96~97 Zhang Zhenyu, Liu Yanhong, Yu Jia, et al. Compoud of polylactide and sutdy of the degradation velocity[J]. Journal of Natural Science of Heilongjiang University, 1998,15(2):96~97(in Chinese) -
点击查看大图
计量
- 文章访问数: 1466
- HTML全文浏览量: 210
- PDF下载量: 5
- 被引次数: 0
下载:
