Abstract: For the feature that hypersonic vehicle motion model is highly nonlinear, multivariable coupled and includes uncertain parameters, a robust adaptive control strategy based on nonlinear dynamic inversion for the hypersonic vehicle was proposed. By decomposing the vehicle motion equations into two subsystems, namely, a velocity subsystem and an altitude subsystem, and incorporating the design of virtual control commands and nonlinear dynamic inversion technology, the stable velocity and altitude tracking were achieved. To eliminate the effect of the model uncertainties and external disturbances, the robust adaptive sliding mode control method was adopted. Simulation results show that the proposed method not only satisfies the velocity and altitude tracking performance requirements, but also is robust to model uncertainties and external disturbances.