Abstract: An open-loop memory polynomial pre-distorter based on look-up table was proposed. Both memory polynomial model(MPM) pre-distorter coefficient estimates and the implementation of signal pre-distortion processing were considered. First, with the complementarity on the transmission characteristics for pre-distorter and high power amplifier(HPA), the memory polynomial coefficient was extracted by using once least squares algorithm using sampling input and output signal of power amplifier. Therefore our scheme eliminates convergence issue and reduce calculated amount in iterative architecture which emerged in traditional pre-distorters. And then, by analyzing the feature of memory polynomial pre-distorter, one-dimensional vector table look-up was established, which based on look-up the index of amplitude of input signal. With power-accumulate operations in MPM pre-distorter was implemented through the look-up table, dramatically reduce the cost of computing and hardware for implementing pre-distorter. The simulation results show that, the proposed pre-distorter can effectively compensate memory nonlinearity distortion of system due to high-power amplifier, and the power spectrum characteristics improves approximately 20 dB in the valid bandwidth. Therefore, our scheme can dramatically improve the system bit error rate performance.