Abstract: The blended wing body (BWB) commercial aircraft configuration has become a hot topic and has been widely studied around the world. As a new configuration, its cabin design is very different from the conventional, so it-s necessary to study the new problems with the BWB cabin design. Focused on the marked traits, some basic cabin-relative issues were studied. The cabin layout must meet the CCAR-25 criteria, as well as the passengers- comfort need, so the cabin related airworthiness and comfort items were firstly abstracted. A cabin layout solution and the accompanying parameterization method were followed. The 250 seating BWB transport was then taken as example for the details of layout design. The results show that the parameterization method of the cabin layout is feasible for the need of a BWB family. However, such requirements as emergent evacuation within 90 seconds must be further highlighted and verified by experiments.