生物芯片点样机器人样品分配机理分析

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名

邮箱

手机号码

标题

留言内容

验证码

Analysis on liquid dispensing principles of robot for fabricating biochip

School of Mechanical Engineering and Automation, Beijing University of Aeronautics and Astronautics, Beijing 100083, China

摘要: 为了解决接触式点样法制备生物芯片过程中,点样样点大小如何估算的问题,对样品分配机理进行了理论分析,讨论了点样针针尖大小、点样速度及溶液表面张力系数等因素对点样样点大小的影响,并进行了试验验证.最后根据试验数据总结出了点样样点的估算公式,为生物芯片制备中相关参数的选取提供了依据.
- 机器人 /
- 生物芯片 /
- 样品分配 /
- 点样针
Abstract: In order to solve the problem of estimating the sample spots diameters in fabricating biochip, the liquid dispensing principles were analyzed. The affections to the sample spots diameters by the factors, such us the tip diameters, printing velocities, and liquid characters, were tested and discussed. According to the experimental datum, the estimation formula of sample spots diameters was put forward. The research result is helpful to select correct parameters in fabricating biochip.
- robot /
- biochip /
- sample liquid dispensing /
- printing pin

[1]	Xiang C C,Chen Yidong．cDNA microarray technology and its application[J]. Biotechnol Advance,2000,18:35~46
[2]	赵东,周强,毕树生,等．用于生物芯片制备的点样机器人系统[J]．机器人,2002,24(2):149~153 Zhao Dong,Zhou Qiang,Bi Shusheng,et al．Robot system to make biochip microarrays [J]．Robot,2002,24(2):149~153(in Chinese)
[3]	朱步瑶,赵振国．界面化学基础[M]．北京:化学工业出版社,1996 Zhu Buyao,Zhao Zhenguo．The rationale of interface chemistry[M]． Beijing:Chemical Industry Press,1996(in Chinese)
[4]	Rose D, Faughn M．DNA microarray handbook ．1999-01-01
[5]	黄海燕,韩金祥．基因芯片接触式点样条件的优化[J]．生物技术通讯,2003,14(2):119~122 Huang Haiyan,Han Jinxiang．Optimization of microarray contacting printing[J]．Letters in Biotechnology,2003,14(2):119~122(in Chinese)

点击查看大图